Does Oxycodone Interact with Oxycodone Hydrochloride?
Oxycodone and Oxycodone Hydrochloride have a major drug interaction according to U.S. FDA drug labeling data. Discontinue Oxycodone hydrochloride oral solution if serotonin syndrome is suspected. ( 7 ) Monoamine Oxidase Inhibitors (MAOIs): Can potentiate the effects of oxycodone. ( 7 ) Mixed Agonist/Antagonist and Partial Agonist Opioid Analgesics: Avoid use with Oxycodone hydrochloride oral solution because they may reduce analgesic effect of Oxycodone hydrochloride oral solution or precipitate withdrawal symptoms. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Oxycodone Class
- Opioid Agonist
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Oxycodone and your doctor is considering prescribing Oxycodone Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider