Does Paroxetine Interact with Thioridazine Hydrochloride?
Paroxetine and Thioridazine Hydrochloride have a contraindicated drug interaction according to U.S. FDA drug labeling data. Inhibits CYP450 2D6, elevating thioridazine levels and augmenting QTc prolongation, risking serious cardiac arrhythmias including Torsades de pointes. The mechanism involves cyp450 2d6 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Contraindicated
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Paroxetine and Thioridazine Hydrochloride occurs because cyp450 2d6 inhibition. Clinically, this means inhibits cyp450 2d6, elevating thioridazine levels and augmenting qtc prolongation, risking serious cardiac arrhythmias including torsades de pointes. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.
What To Tell Your Doctor or Pharmacist
If you are taking Paroxetine and your doctor is considering prescribing Thioridazine Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider