Does Phenylephrine Hydrochloride Injection Solution Interact with Methylergonovine Maleate?
CDI records a major classification for Phenylephrine Hydrochloride Injection Solution and Methylergonovine Maleate. The stored summary is: Ergot alkaloid increases pressor effect of phenylephrine hydrochloride. The mechanism involves agonistic effects with ergot alkaloids. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Phenylephrine Hydrochloride Injection Solution Class
- alpha-1 Adrenergic Agonist
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Agonistic effects with ergot alkaloids
What To Tell Your Doctor or Pharmacist
If you are taking Phenylephrine Hydrochloride Injection Solution and your doctor is considering prescribing Methylergonovine Maleate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider