Does Phenytoin Interact with Fentanyl?
Phenytoin and Fentanyl have a major drug interaction according to U.S. FDA drug labeling data. CYP3A4 inducer that decreases fentanyl plasma concentration, resulting in decreased efficacy and withdrawal syndrome. Discontinuation may cause serious respiratory depression. The mechanism involves cyp3a4 induction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Phenytoin Class
- Anti-epileptic Agent
- Fentanyl Class
- Opioid Agonist
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Phenytoin and Fentanyl occurs because cyp3a4 induction. Clinically, this means cyp3a4 inducer that decreases fentanyl plasma concentration, resulting in decreased efficacy and withdrawal syndrome. discontinuation may cause serious respiratory depression. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Phenytoin and your doctor is considering prescribing Fentanyl (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider