Does Promethazine Phenylephrine Codeine Interact with Diuretics?
Promethazine Phenylephrine Codeine and Diuretics have a moderate drug interaction according to U.S. FDA drug labeling data. Codeine may reduce the efficacy of diuretics. Monitor for reduced effect. The mechanism involves codeine effect on diuretic efficacy. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Promethazine Phenylephrine Codeine and Diuretics occurs because codeine effect on diuretic efficacy. Clinically, this means codeine may reduce the efficacy of diuretics. monitor for reduced effect. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Promethazine Phenylephrine Codeine and your doctor is considering prescribing Diuretics (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider