Protease Inhibitors + Ezetimibe And Simvastatin Interaction
Contraindicatedinteraction on record
Description
Strong CYP3A4 inhibitors that increase simvastatin plasma levels, elevating risk of myopathy and rhabdomyolysis.
Mechanism
Reduces elimination of simvastatin component via CYP3A4 inhibition
Source: NLP:ezetimibe and simvastatin