Quinidine + Tramadol Hydrochloride Interaction

Majorinteraction on record

Description

CYP2D6 inhibitor may increase tramadol plasma concentration and decrease M1 concentration, resulting in increased risk of seizures, serotonin syndrome, and opioid withdrawal or toxicity.

Mechanism

Inhibition of CYP2D6 metabolism

Source: NLP:tramadol hydrochloride