Does Ramipril Interact with Telmisartan And Amlodipine?
Ramipril and Telmisartan And Amlodipine have a moderate drug interaction according to U.S. FDA drug labeling data. Co-administration increases steady-state Cmax and AUC of ramipril and ramiprilat (2.3-2.4 fold and 2.1-1.5 fold respectively) with additive pharmacodynamic effects possible. The mechanism involves increased ramipril and ramiprilat exposure with additive pharmacodynamic effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Ramipril Class
- Angiotensin Converting Enzyme Inhibitor
- Telmisartan And Amlodipine Class
- Angiotensin 2 Receptor Blocker
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Ramipril and Telmisartan And Amlodipine occurs because increased ramipril and ramiprilat exposure with additive pharmacodynamic effects. Clinically, this means co-administration increases steady-state cmax and auc of ramipril and ramiprilat (2.3-2.4 fold and 2.1-1.5 fold respectively) with additive pharmacodynamic effects possible. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Ramipril and your doctor is considering prescribing Telmisartan And Amlodipine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider