Does Ramipril Interact with Telmisartan And Hydrochlorothiazide?
Ramipril and Telmisartan And Hydrochlorothiazide have a major drug interaction according to U.S. FDA drug labeling data. Co-administration increases ramipril and ramiprilat exposure (2.3-2.4 fold Cmax, 1.5-2.1 fold AUC) while decreasing telmisartan levels. Additive pharmacodynamic effects may occur. The mechanism involves additive pharmacodynamic effects and increased ramipril/ramiprilat exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Ramipril Class
- Angiotensin Converting Enzyme Inhibitor
- Telmisartan And Hydrochlorothiazide Class
- Angiotensin 2 Receptor Blocker
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Ramipril and Telmisartan And Hydrochlorothiazide occurs because additive pharmacodynamic effects and increased ramipril/ramiprilat exposure. Clinically, this means co-administration increases ramipril and ramiprilat exposure (2.3-2.4 fold cmax, 1.5-2.1 fold auc) while decreasing telmisartan levels. additive pharmacodynamic effects may occur. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Ramipril and your doctor is considering prescribing Telmisartan And Hydrochlorothiazide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider