Does Rasagiline Interact with Ciprofloxacin?
CDI records a moderate classification for Rasagiline and Ciprofloxacin. The stored summary is: CYP1A2 inhibitor that may increase rasagiline plasma concentrations up to 2-fold, resulting in increased adverse events. Dose limit to 0.5 mg once daily. The mechanism involves cyp1a2 inhibition reducing rasagiline metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Ciprofloxacin Class
- Fluoroquinolone Antibacterial
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
CYP1A2 inhibition reducing rasagiline metabolism
What To Tell Your Doctor or Pharmacist
If you are taking Rasagiline and your doctor is considering prescribing Ciprofloxacin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider