Does Rifabutin Interact with Norethindrone?
CDI records a moderate classification for Rifabutin and Norethindrone. The stored summary is: May decrease systemic concentrations of norethindrone and potentially diminish contraceptive effectiveness or increase breakthrough bleeding. The mechanism involves cyp3a4 enzyme induction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Rifabutin Class
- Rifamycin Antimycobacterial
- Norethindrone Class
- Progestin
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
CYP3A4 enzyme induction
What To Tell Your Doctor or Pharmacist
If you are taking Rifabutin and your doctor is considering prescribing Norethindrone (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider