Does Rifabutin Interact with Rilpivirine Hydrochloride?
Rifabutin and Rilpivirine Hydrochloride have a moderate drug interaction according to U.S. FDA drug labeling data. Concomitant use may cause decrease in rilpivirine plasma concentrations. Rilpivirine dose should be increased from 25 mg once daily to 50 mg once daily during coadministration. The mechanism involves cyp3a enzyme induction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Rifabutin Class
- Rifamycin Antimycobacterial
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Rifabutin and Rilpivirine Hydrochloride occurs because cyp3a enzyme induction. Clinically, this means concomitant use may cause decrease in rilpivirine plasma concentrations. rilpivirine dose should be increased from 25 mg once daily to 50 mg once daily during coadministration. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Rifabutin and your doctor is considering prescribing Rilpivirine Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider