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Does Rifampin Interact with Cotrimoxazole?

Rifampin and Cotrimoxazole have a unknown drug interaction according to U.S. FDA drug labeling data. Concomitant use with probenecid and cotrimoxazole increases the concentration of rifampin which may increase the risk of RIFADIN toxicities. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Unknown
Rifampin Class
Rifamycin Antibacterial
Cotrimoxazole Class
Azole Antifungal
Management
Consult your pharmacist
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Rifampin and your doctor is considering prescribing Cotrimoxazole (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Rifampin(Rifadin)+💊 Cotrimoxazole(Fungicure Solution)

Severity & Interaction Details

ℹ️
unknown
Interaction documented — severity unclassified
The FDA label notes an interaction but the severity is not classified in our dataset.
Severity scale
MinorContra
On record
Yes
Drug A class
Rifamycin Antibacterial
Drug B class
Azole Antifungal
Source
FDA drug label - rifampin

What this means in plain English

Concomitant use with probenecid and cotrimoxazole increases the concentration of rifampin which may increase the risk of RIFADIN toxicities.

About Rifampin and Cotrimoxazole

Rifampin is a Rifamycin Antibacterial, while Cotrimoxazole is an Azole Antifungal. You may recognize them by the brand names Rifadin and Dermatin. Rifampin is taken by mouth, whereas Cotrimoxazole is applied to the skin.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.