Home›Rifampin›Rifampin + Teriflunomide

Does Rifampin Interact with Teriflunomide?

Rifampin and Teriflunomide have a moderate drug interaction according to U.S. FDA drug labeling data. Teriflunomide may increase exposure of rifampin. Consider reducing dose and monitor patients closely. The mechanism involves oatp1b1/b3 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Rifampin Class
Rifamycin Antibacterial
Teriflunomide Class
Pyrimidine Synthesis Inhibitor
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Rifampin and Teriflunomide occurs because oatp1b1/b3 inhibition. Clinically, this means teriflunomide may increase exposure of rifampin. consider reducing dose and monitor patients closely. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.

What To Tell Your Doctor or Pharmacist

If you are taking Rifampin and your doctor is considering prescribing Teriflunomide (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Rifampin(Rifadin)+💊 Teriflunomide(Aubagio)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
Rifamycin Antibacterial
Drug B class
Pyrimidine Synthesis Inhibitor
Source
NLP:teriflunomide

What this means in plain English

Teriflunomide may increase exposure of rifampin. Consider reducing dose and monitor patients closely.

About Rifampin and Teriflunomide

Rifampin is a Rifamycin Antibacterial, while Teriflunomide is a Pyrimidine Synthesis Inhibitor. You may recognize them by the brand names Rifadin and Aubagio. Both medications are taken by mouth. Teriflunomide additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"OATP1B1/B3 inhibition"

📖 Source: NLP:teriflunomide

Share this result:

WhatsAppText / SMSEmail
Also share on:XFacebook
Add more drugs
Check Rifampin and Teriflunomide against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →
Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.