Rilpivirine + Azithromycin Interaction
Unknowninteraction on record
Description
Macrolide or ketolide antibiotics: azithromycin clarithromycin erythromycin ↑ rilpivirine ↔ azithromycin ↔ clarithromycin ↔ erythromycin Macrolides are expected to increase concentrations of rilpivirine and are associated with a risk of Torsade de Pointes [Warnings and Precautions (5.4) ] . Where possible, consider alternatives, such as azithromycin, which increases rilpivirine concentrations less than other macrolides Narcotic Analgesics: methadone * ↓ R(-) methadone ↓ S(+) methadone No dose adjustments are required when initiating coadministration of methadone with rilpivirine tablets.
Source: FDA drug label - rilpivirine