Does Rivaroxaban Interact with Clarithromycin?
CDI records a minor classification for Rivaroxaban and Clarithromycin. The stored summary is: Combined P-gp and strong CYP3A inhibitor, but pharmacokinetic data suggests no precautions necessary as exposure change unlikely to affect bleeding risk. The mechanism involves inhibition of cyp3a4/5 and p-gp transporters. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Minor
- Rivaroxaban Class
- Factor Xa Inhibitor
- Clarithromycin Class
- Macrolide Antimicrobial
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Inhibition of CYP3A4/5 and P-gp transporters
What To Tell Your Doctor or Pharmacist
If you are taking Rivaroxaban and your doctor is considering prescribing Clarithromycin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider