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Does Ropivacaine Hydrochloride Interact with Hydroxyurea?

Ropivacaine Hydrochloride and Hydroxyurea have a major drug interaction according to U.S. FDA drug labeling data. Increased risk of developing methemoglobinemia when concurrently exposed to hydroxyurea. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Hydroxyurea Class
Antimetabolite
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Ropivacaine Hydrochloride and your doctor is considering prescribing Hydroxyurea (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Ropivacaine Hydrochloride(Naropin)+💊 Hydroxyurea(Hydrea)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Antimetabolite
Source
NLP:ropivacaine hydrochloride

What this means in plain English

Increased risk of developing methemoglobinemia when concurrently exposed to hydroxyurea.

About Ropivacaine Hydrochloride and Hydroxyurea

Hydroxyurea is an Antimetabolite. You may recognize them by the brand names Naropin and Hydrea. Ropivacaine Hydrochloride is given as an epidural, whereas Hydroxyurea is taken by mouth. Hydroxyurea additionally carries an FDA boxed warning, the FDA's strongest safety alert.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.