Does Rosuvastatin Interact with Momelotinib?
Rosuvastatin and Momelotinib have a moderate drug interaction according to U.S. FDA drug labeling data. Momelotinib is a BCRP inhibitor that may increase rosuvastatin exposure. Initiate rosuvastatin at 5 mg and do not increase beyond 10 mg once daily. The mechanism involves bcrp inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Rosuvastatin Class
- HMG-CoA Reductase Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Rosuvastatin and Momelotinib occurs because bcrp inhibition. Clinically, this means momelotinib is a bcrp inhibitor that may increase rosuvastatin exposure. initiate rosuvastatin at 5 mg and do not increase beyond 10 mg once daily. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Rosuvastatin and your doctor is considering prescribing Momelotinib (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider