Salicylates + Methotrexate Interaction
Majorinteraction on record
Description
Caution should be used when salicylates are administered concomitantly with methotrexate. These drugs reduce tubular secretion of methotrexate and may displace it from serum albumin binding, enhancing toxicity.
Mechanism
Reduce tubular secretion and displace methotrexate from serum albumin binding
Source: NLP:methotrexate