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Does Selective Serotonin Reuptake Inhibitors Ssri Interact with Celecoxib?

Selective Serotonin Reuptake Inhibitors Ssri and Celecoxib have a moderate drug interaction according to U.S. FDA drug labeling data. Concomitant use potentiates bleeding risk more than NSAID alone by affecting platelet serotonin release. Monitor for signs of bleeding. The mechanism involves serotonin reuptake inhibition potentiates platelet dysfunction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Celecoxib Class
Nonsteroidal Anti-inflammatory Drug
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Selective Serotonin Reuptake Inhibitors Ssri and Celecoxib occurs because serotonin reuptake inhibition potentiates platelet dysfunction. Clinically, this means concomitant use potentiates bleeding risk more than nsaid alone by affecting platelet serotonin release. monitor for signs of bleeding. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.

What To Tell Your Doctor or Pharmacist

If you are taking Selective Serotonin Reuptake Inhibitors Ssri and your doctor is considering prescribing Celecoxib (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Selective Serotonin Reuptake Inhibitors Ssri+💊 Celecoxib(Celecoxib)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Nonsteroidal Anti-inflammatory Drug
Source
NLP:celecoxib

What this means in plain English

Concomitant use potentiates bleeding risk more than NSAID alone by affecting platelet serotonin release. Monitor for signs of bleeding.

What the FDA label says

"Serotonin reuptake inhibition potentiates platelet dysfunction"

📖 Source: NLP:celecoxib

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.