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Does Selective Serotonin Reuptake Inhibitors Ssri Interact with Naltrexone Hydrochloride And Bupropion Hydrochloride?

Selective Serotonin Reuptake Inhibitors Ssri and Naltrexone Hydrochloride And Bupropion Hydrochloride have a moderate drug interaction according to U.S. FDA drug labeling data. Bupropion inhibits CYP2D6 and can increase SSRI concentrations. Consider dose reduction when using with CONTRAVE. The mechanism involves cyp2d6 inhibition by bupropion. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Selective Serotonin Reuptake Inhibitors Ssri and Naltrexone Hydrochloride And Bupropion Hydrochloride occurs because cyp2d6 inhibition by bupropion. Clinically, this means bupropion inhibits cyp2d6 and can increase ssri concentrations. consider dose reduction when using with contrave. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.

What To Tell Your Doctor or Pharmacist

If you are taking Selective Serotonin Reuptake Inhibitors Ssri and your doctor is considering prescribing Naltrexone Hydrochloride And Bupropion Hydrochloride (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Selective Serotonin Reuptake Inhibitors Ssri+💊 Naltrexone Hydrochloride And Bupropion Hydrochloride(Contrave Extended-Release)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:naltrexone hydrochloride and bupropion hydrochloride

What this means in plain English

Bupropion inhibits CYP2D6 and can increase SSRI concentrations. Consider dose reduction when using with CONTRAVE.

What the FDA label says

"CYP2D6 inhibition by bupropion"

📖 Source: NLP:naltrexone hydrochloride and bupropion hydrochloride

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.