Does Simvastatin Interact with Trandolapril And Verapamil Hydrochloride?
Simvastatin and Trandolapril And Verapamil Hydrochloride have a unknown drug interaction according to U.S. FDA drug labeling data. Co-administration of multiple doses of 10 mg of verapamil with 80 mg simvastatin resulted in exposure to simvastatin 2.5-fold that following simvastatin alone. Limit the dose of simvastatin in patients on verapamil to 10 mg daily. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Simvastatin Class
- HMG-CoA Reductase Inhibitor
- Trandolapril And Verapamil Hydrochloride Class
- Angiotensin Converting Enzyme Inhibitor
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Simvastatin and your doctor is considering prescribing Trandolapril And Verapamil Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider