Does Simvastatin Interact with Valsartan And Hydrochlorothiazide?
Simvastatin and Valsartan And Hydrochlorothiazide have a moderate drug interaction according to U.S. FDA drug labeling data. Impact of Amlodipine on Other Drugs Simvastatin: Coadministration of simvastatin with amlodipine increases the systemic exposure of simvastatin. Limit the dose of simvastatin in patients on amlodipine to 20 mg daily [ see Clinical Pharmacology ( 12.3 ) ]. If simvastatin is coadministered with amlodipine, do not exceed doses greater than 20 mg daily of simvastatin ( 7 ) Antidiabetic drugs: Dosage adjustment of antidiabetic may be required ( 7 ) Cholestyramine and colestipol: Reduced absorption of thiazides ( 12.3 ) Lithium: Increased risk of lithium toxicity. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Simvastatin Class
- HMG-CoA Reductase Inhibitor
- Valsartan And Hydrochlorothiazide Class
- Angiotensin 2 Receptor Blocker
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Simvastatin and your doctor is considering prescribing Valsartan And Hydrochlorothiazide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider