Does St Johns Wort Interact with Valsartan And Hydrochlorothiazide?
CDI records a moderate classification for St Johns Wort and Valsartan And Hydrochlorothiazide. The stored summary is: CYP3A inducer that may decrease amlodipine efficacy. Blood pressure should be closely monitored when amlodipine is coadministered with St. John's Wort. The mechanism involves cyp3a induction may decrease amlodipine systemic exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Valsartan And Hydrochlorothiazide Class
- Angiotensin 2 Receptor Blocker
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
CYP3A induction may decrease amlodipine systemic exposure
What To Tell Your Doctor or Pharmacist
If you are taking St Johns Wort and your doctor is considering prescribing Valsartan And Hydrochlorothiazide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider