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Does St Johns Wort Interact with Valsartan And Hydrochlorothiazide?

St Johns Wort and Valsartan And Hydrochlorothiazide have a moderate drug interaction according to U.S. FDA drug labeling data. CYP3A inducer that may decrease amlodipine efficacy. Blood pressure should be closely monitored when amlodipine is coadministered with St. John's Wort. The mechanism involves cyp3a induction may decrease amlodipine systemic exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Valsartan And Hydrochlorothiazide Class
Angiotensin 2 Receptor Blocker
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between St Johns Wort and Valsartan And Hydrochlorothiazide occurs because cyp3a induction may decrease amlodipine systemic exposure. Clinically, this means cyp3a inducer that may decrease amlodipine efficacy. blood pressure should be closely monitored when amlodipine is coadministered with st. john's wort. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.

What To Tell Your Doctor or Pharmacist

If you are taking St Johns Wort and your doctor is considering prescribing Valsartan And Hydrochlorothiazide (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 St Johns Wort+💊 Valsartan And Hydrochlorothiazide(Valsartan And Hydrochlorothiazide)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Angiotensin 2 Receptor Blocker
Source
NLP:amlodipine besylate valsartan hydrochlorothiazide

What this means in plain English

CYP3A inducer that may decrease amlodipine efficacy. Blood pressure should be closely monitored when amlodipine is coadministered with St. John's Wort.

What the FDA label says

"CYP3A induction may decrease amlodipine systemic exposure"

📖 Source: NLP:amlodipine besylate valsartan hydrochlorothiazide

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.