St. John'S Wort + Velpatasvir And Sofosbuvir Interaction
Majorinteraction on record
Description
P-gp and moderate to strong CYP inducer that may decrease concentrations of sofosbuvir and/or velpatasvir, leading to reduced therapeutic effect. Use not recommended.
Mechanism
Induction of P-gp and CYP2B6, CYP2C8, or CYP3A4
Source: NLP:velpatasvir and sofosbuvir