Velpatasvir And Sofosbuvir has 23 known drug interactions based on U.S. FDA drug labeling data. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Carbamazepine, Rifampin, Rosuvastatin. Patients taking Velpatasvir And Sofosbuvir should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 23
- Major
- 5
- Moderate
- 7
Major (5)
- Velpatasvir And Sofosbuvir + Carbamazepine— P-gp and moderate to strong CYP inducer that may decrease concentrations of sofosbuvir and/or velpatasvir, leading to re…
- Velpatasvir And Sofosbuvir + Rifampin— P-gp and moderate to strong CYP inducer that may decrease concentrations of sofosbuvir and/or velpatasvir, leading to re…
- Velpatasvir And Sofosbuvir + Rosuvastatin— Combination increases rosuvastatin exposure. Limit rosuvastatin dose to 10 mg once daily.
- Velpatasvir And Sofosbuvir + Rosuvastatin Calcium— Increases rosuvastatin exposure. Limit rosuvastatin dose to 10 mg once daily.
- Velpatasvir And Sofosbuvir + St. John'S Wort— P-gp and moderate to strong CYP inducer that may decrease concentrations of sofosbuvir and/or velpatasvir, leading to re…
Moderate (7)
- Velpatasvir And Sofosbuvir + Atorvastatin— atorvastatin ↑ atorvastatin Coadministration of EPCLUSA with atorvastatin may be associated with increased risk of myopa…
- Velpatasvir And Sofosbuvir + Doravirine, Lamivudine, And Tenofovir Disoproxil Fumarate— Co-administration increases tenofovir plasma concentrations. Monitor for adverse reactions associated with tenofovir dis…
- Velpatasvir And Sofosbuvir + Lamivudine And Tenofovir Disoproxil Fumarate— Increases tenofovir exposure. Monitor for adverse reactions associated with tenofovir.
- Velpatasvir And Sofosbuvir + Sofosbuvir— John's wort, carbamazepine): May decrease concentrations of sofosbuvir and/or velpatasvir. Use of sofosbuvir and velpata…
- Velpatasvir And Sofosbuvir + Tenofovir— Regimens containing tenofovir DF ↑ tenofovir Monitor for tenofovir-associated adverse reactions in patients receiving EP…
- Velpatasvir And Sofosbuvir + Velpatasvir— John's wort, carbamazepine): May decrease concentrations of sofosbuvir and/or velpatasvir. Use of sofosbuvir and velpata…
- Velpatasvir And Sofosbuvir + Warfarin— Frequent monitoring of INR and dose adjustments may be necessary due to HCV clearance-related changes in hepatic functio…