Does Sumatriptan Interact with Methysergide?
CDI records a contraindicated classification for Sumatriptan and Methysergide. The stored summary is: Ergot-type medication causing prolonged vasospastic reactions with additive effects. Use within 24 hours of sumatriptan is contraindicated. The mechanism involves additive vasospastic effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Sumatriptan Class
- Serotonin-1b and Serotonin-1d Receptor Agonist
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Additive vasospastic effects
What To Tell Your Doctor or Pharmacist
If you are taking Sumatriptan and your doctor is considering prescribing Methysergide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider