Does Tacrolimus Interact with Amiloride Hydrochloride?
Tacrolimus and Amiloride Hydrochloride have a moderate drug interaction according to U.S. FDA drug labeling data. Risk of hyperkalemia may be increased when used concomitantly with amiloride HCl. Requires caution and frequent monitoring of serum potassium. The mechanism involves both agents increase serum potassium levels. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Tacrolimus Class
- Calcineurin Inhibitor Immunosuppressant
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Tacrolimus and Amiloride Hydrochloride occurs because both agents increase serum potassium levels. Clinically, this means risk of hyperkalemia may be increased when used concomitantly with amiloride hcl. requires caution and frequent monitoring of serum potassium. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Tacrolimus and your doctor is considering prescribing Amiloride Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider