Does Tacrolimus Interact with Diltiazem?
Tacrolimus and Diltiazem have a moderate drug interaction according to U.S. FDA drug labeling data. Mild or moderate CYP3A inhibitor calcium channel blocker that may affect tacrolimus concentrations. Monitor tacrolimus whole blood trough concentrations. The mechanism involves mild to moderate cyp3a inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Tacrolimus Class
- Calcineurin Inhibitor Immunosuppressant
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Tacrolimus and Diltiazem occurs because mild to moderate cyp3a inhibition. Clinically, this means mild or moderate cyp3a inhibitor calcium channel blocker that may affect tacrolimus concentrations. monitor tacrolimus whole blood trough concentrations. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Tacrolimus and your doctor is considering prescribing Diltiazem (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider