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Does Telmisartan And Amlodipine Interact with Ramipril?

Telmisartan And Amlodipine and Ramipril have a moderate drug interaction according to U.S. FDA drug labeling data. Co-administration increases steady-state Cmax and AUC of ramipril and ramiprilat (2.3-2.4 fold and 2.1-1.5 fold respectively) with additive pharmacodynamic effects possible. The mechanism involves increased ramipril and ramiprilat exposure with additive pharmacodynamic effects. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Telmisartan And Amlodipine Class
Angiotensin 2 Receptor Blocker
Ramipril Class
Angiotensin Converting Enzyme Inhibitor
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Telmisartan And Amlodipine and Ramipril occurs because increased ramipril and ramiprilat exposure with additive pharmacodynamic effects. Clinically, this means co-administration increases steady-state cmax and auc of ramipril and ramiprilat (2.3-2.4 fold and 2.1-1.5 fold respectively) with additive pharmacodynamic effects possible. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.

What To Tell Your Doctor or Pharmacist

If you are taking Telmisartan And Amlodipine and your doctor is considering prescribing Ramipril (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Telmisartan And Amlodipine(Telmisartan And Amlodipine)+💊 Ramipril(Ramipril)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
Angiotensin 2 Receptor Blocker
Drug B class
Angiotensin Converting Enzyme Inhibitor
Source
NLP:telmisartan and amlodipine

What this means in plain English

Co-administration increases steady-state Cmax and AUC of ramipril and ramiprilat (2.3-2.4 fold and 2.1-1.5 fold respectively) with additive pharmacodynamic effects possible.

What the FDA label says

"Increased ramipril and ramiprilat exposure with additive pharmacodynamic effects"

📖 Source: NLP:telmisartan and amlodipine

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.