Does Telmisartan And Hydrochlorothiazide Interact with Ramipril?
CDI records a major classification for Telmisartan And Hydrochlorothiazide and Ramipril. The stored summary is: Co-administration increases ramipril and ramiprilat exposure (2.3-2.4 fold Cmax, 1.5-2.1 fold AUC) while decreasing telmisartan levels. Additive pharmacodynamic effects may occur. The mechanism involves additive pharmacodynamic effects and increased ramipril/ramiprilat exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Telmisartan And Hydrochlorothiazide Class
- Angiotensin 2 Receptor Blocker
- Ramipril Class
- Angiotensin Converting Enzyme Inhibitor
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Additive pharmacodynamic effects and increased ramipril/ramiprilat exposure
What To Tell Your Doctor or Pharmacist
If you are taking Telmisartan And Hydrochlorothiazide and your doctor is considering prescribing Ramipril (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider