Does Telmisartan And Hydrochlorothiazide Interact with Warfarin?
Telmisartan And Hydrochlorothiazide and Warfarin have a minor drug interaction according to U.S. FDA drug labeling data. Telmisartan slightly decreased mean warfarin trough plasma concentration, but this did not result in a change in INR. The mechanism involves minor decrease in warfarin plasma concentration. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Telmisartan And Hydrochlorothiazide Class
- Angiotensin 2 Receptor Blocker
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Telmisartan And Hydrochlorothiazide and Warfarin occurs because minor decrease in warfarin plasma concentration. Clinically, this means telmisartan slightly decreased mean warfarin trough plasma concentration, but this did not result in a change in inr. This is classified as a minor interaction with generally low clinical significance, though your healthcare provider should still be informed that you are taking both medications.
What To Tell Your Doctor or Pharmacist
If you are taking Telmisartan And Hydrochlorothiazide and your doctor is considering prescribing Warfarin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider