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Does Tetracycline Interact with Trastuzumab?

Tetracycline and Trastuzumab have a major drug interaction according to U.S. FDA drug labeling data. Patients receiving anthracyclines after stopping trastuzumab may be at increased risk of cardiac dysfunction due to trastuzumab's long washout period. Avoid anthracycline-based therapy for up to 7 months after stopping trastuzumab if possible. The mechanism involves trastuzumab's long washout period increases cardiac dysfunction risk when combined with anthracyclines. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Trastuzumab Class
HER2/neu Receptor Antagonist
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Tetracycline and Trastuzumab occurs because trastuzumab's long washout period increases cardiac dysfunction risk when combined with anthracyclines. Clinically, this means patients receiving anthracyclines after stopping trastuzumab may be at increased risk of cardiac dysfunction due to trastuzumab's long washout period. avoid anthracycline-based therapy for up to 7 months after stopping trastuzumab if possible. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Tetracycline and your doctor is considering prescribing Trastuzumab (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Tetracycline+💊 Trastuzumab

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
HER2/neu Receptor Antagonist
Source
NLP:trastuzumab

What this means in plain English

Patients receiving anthracyclines after stopping trastuzumab may be at increased risk of cardiac dysfunction due to trastuzumab's long washout period. Avoid anthracycline-based therapy for up to 7 months after stopping trastuzumab if possible.

What the FDA label says

"Trastuzumab's long washout period increases cardiac dysfunction risk when combined with anthracyclines"

📖 Source: NLP:trastuzumab

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.