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Does Theophylline Interact with Adalimumab Aacf?

Theophylline and Adalimumab Aacf have a moderate drug interaction according to U.S. FDA drug labeling data. ADALIMUMAB-AACF may influence CYP450 enzyme formation, affecting theophylline metabolism. Monitoring of theophylline concentration is recommended upon initiation or discontinuation of ADALIMUMAB-AACF. The mechanism involves antagonism of cytokine activity may suppress cyp450 enzyme formation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Theophylline Class
Methylxanthine
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Theophylline and Adalimumab Aacf occurs because antagonism of cytokine activity may suppress cyp450 enzyme formation. Clinically, this means adalimumab-aacf may influence cyp450 enzyme formation, affecting theophylline metabolism. monitoring of theophylline concentration is recommended upon initiation or discontinuation of adalimumab-aacf. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.

What To Tell Your Doctor or Pharmacist

If you are taking Theophylline and your doctor is considering prescribing Adalimumab Aacf (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Theophylline(Theophylline)+💊 Adalimumab Aacf(Idacio)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
Methylxanthine
Drug B class
—
Source
NLP:adalimumab-aacf

What this means in plain English

ADALIMUMAB-AACF may influence CYP450 enzyme formation, affecting theophylline metabolism. Monitoring of theophylline concentration is recommended upon initiation or discontinuation of ADALIMUMAB-AACF.

What the FDA label says

"Antagonism of cytokine activity may suppress CYP450 enzyme formation"

📖 Source: NLP:adalimumab-aacf

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.