Does Theophylline Interact with Regadenoson?
Theophylline and Regadenoson have a moderate drug interaction according to U.S. FDA drug labeling data. Methylxanthine that interferes with the vasodilation activity of regadenoson. Patients should avoid consumption for at least 12 hours before regadenoson administration. The mechanism involves non-specific adenosine receptor antagonism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Theophylline Class
- Methylxanthine
- Regadenoson Class
- Adenosine Receptor Agonist
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Theophylline and Regadenoson occurs because non-specific adenosine receptor antagonism. Clinically, this means methylxanthine that interferes with the vasodilation activity of regadenoson. patients should avoid consumption for at least 12 hours before regadenoson administration. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Theophylline and your doctor is considering prescribing Regadenoson (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider