Does Tipranavir Interact with Midazolam?
Tipranavir and Midazolam have a major drug interaction according to U.S. FDA drug labeling data. Probe substrate for CYP3A4/5; potent inhibition of both hepatic and intestinal CYP3A4/5 observed after first dose and steady state with APTIVUS/ritonavir. The mechanism involves potent cyp3a4/5 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Tipranavir Class
- Protease Inhibitor
- Midazolam Class
- Benzodiazepine
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Tipranavir and Midazolam occurs because potent cyp3a4/5 inhibition. Clinically, this means probe substrate for cyp3a4/5; potent inhibition of both hepatic and intestinal cyp3a4/5 observed after first dose and steady state with aptivus/ritonavir. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Tipranavir and your doctor is considering prescribing Midazolam (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider