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Does Tizanidine Interact with Teriflunomide?

Tizanidine and Teriflunomide have a moderate drug interaction according to U.S. FDA drug labeling data. Teriflunomide may reduce exposure of tizanidine. Monitor patients and adjust dose as required. The mechanism involves cyp1a2 induction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Teriflunomide Class
Pyrimidine Synthesis Inhibitor
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Tizanidine and Teriflunomide occurs because cyp1a2 induction. Clinically, this means teriflunomide may reduce exposure of tizanidine. monitor patients and adjust dose as required. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.

What To Tell Your Doctor or Pharmacist

If you are taking Tizanidine and your doctor is considering prescribing Teriflunomide (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Tizanidine(Zanaflex)+💊 Teriflunomide(Aubagio)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Pyrimidine Synthesis Inhibitor
Source
NLP:teriflunomide

What this means in plain English

Teriflunomide may reduce exposure of tizanidine. Monitor patients and adjust dose as required.

About Tizanidine and Teriflunomide

Teriflunomide is a Pyrimidine Synthesis Inhibitor. You may recognize them by the brand names Zanaflex and Aubagio. Both medications are taken by mouth. Teriflunomide additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"CYP1A2 induction"

📖 Source: NLP:teriflunomide

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.