Does Tocilizumab Interact with Oral Contraceptives?
Tocilizumab and Oral Contraceptives have a moderate drug interaction according to U.S. FDA drug labeling data. Exercise caution with tocilizumab coadministration as CYP3A4 inhibition may decrease oral contraceptive effectiveness. The mechanism involves increased cyp3a4 metabolism may reduce oral contraceptive exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Tocilizumab Class
- Interleukin-6 Receptor Antagonist
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Tocilizumab and Oral Contraceptives occurs because increased cyp3a4 metabolism may reduce oral contraceptive exposure. Clinically, this means exercise caution with tocilizumab coadministration as cyp3a4 inhibition may decrease oral contraceptive effectiveness. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Tocilizumab and your doctor is considering prescribing Oral Contraceptives (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider