Does Tocilizumab Aazg Interact with Methotrexate?
Tocilizumab Aazg and Methotrexate have a minor drug interaction according to U.S. FDA drug labeling data. Concomitant administration with tocilizumab had no clinically significant effect on methotrexate exposure. The mechanism involves no effect on tocilizumab clearance. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Tocilizumab Aazg Class
- Interleukin-6 Receptor Antagonist
- Methotrexate Class
- Folate Analog Metabolic Inhibitor
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Tocilizumab Aazg and Methotrexate occurs because no effect on tocilizumab clearance. Clinically, this means concomitant administration with tocilizumab had no clinically significant effect on methotrexate exposure. This is classified as a minor interaction with generally low clinical significance, though your healthcare provider should still be informed that you are taking both medications.
What To Tell Your Doctor or Pharmacist
If you are taking Tocilizumab Aazg and your doctor is considering prescribing Methotrexate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider