Does Tolbutamide Interact with Nitisinone?
CDI records a moderate classification for Tolbutamide and Nitisinone. The stored summary is: Nitisinone is a moderate CYP2C9 inhibitor that increases exposure of tolbutamide. Dosage reduction by half is recommended with additional adjustments as needed. The mechanism involves cyp2c9 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Nitisinone Class
- 4-Hydroxyphenyl-Pyruvate Dioxygenase Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
CYP2C9 inhibition
What To Tell Your Doctor or Pharmacist
If you are taking Tolbutamide and your doctor is considering prescribing Nitisinone (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider