Does Tolbutamide Interact with Tipranavir?
Tolbutamide and Tipranavir have a unknown drug interaction according to U.S. FDA drug labeling data. Glimepiride Glipizide Glyburide Pioglitazone Repaglinide Tolbutamide ↔ Glimepiride (CYP2C9) ↔ Glipizide (CYP2C9) ↔ Glyburide (CYP2C9) ↕ Pioglitazone (CYP2C8 and CYP3A4) ↕ Repaglinide (CYP2C8 and CYP3A4) ↔ Tolbutamide (CYP2C9) The effect of TPV/ritonavir on CYP2C8 substrate is not known. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Tipranavir Class
- Protease Inhibitor
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Tolbutamide and your doctor is considering prescribing Tipranavir (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider