Does Tolbutamide Interact with Zafirlukast?
Tolbutamide and Zafirlukast have a moderate drug interaction according to U.S. FDA drug labeling data. Zafirlukast may interact with tolbutamide as it is metabolized by CYP2C9. Care should be exercised when coadministered. The mechanism involves potential inhibition of cytochrome p450 2c9 isoenzyme system. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Zafirlukast Class
- Leukotriene Receptor Antagonist
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Tolbutamide and Zafirlukast occurs because potential inhibition of cytochrome p450 2c9 isoenzyme system. Clinically, this means zafirlukast may interact with tolbutamide as it is metabolized by cyp2c9. care should be exercised when coadministered. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Tolbutamide and your doctor is considering prescribing Zafirlukast (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider