Does Topical Local Anesthetics Interact with Dexmethylphenidate Hydrochloride?
Topical Local Anesthetics and Dexmethylphenidate Hydrochloride have a major drug interaction according to U.S. FDA drug labeling data. Concomitant use may increase risk of sudden blood pressure and heart rate increase during surgery. Avoid use on day of surgery. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Topical Local Anesthetics and your doctor is considering prescribing Dexmethylphenidate Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider