Does Topiramate Interact with Pioglitazone And Glimepiride?
CDI records a moderate classification for Topiramate and Pioglitazone And Glimepiride. The stored summary is: Decreases pioglitazone and active metabolite exposure. Monitor patients for adequate glycemic control when used concomitantly. The mechanism involves unknown mechanism results in decreased pioglitazone exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Topiramate Class
- Cytochrome P450 3A4 Inducers
- Pioglitazone And Glimepiride Class
- Sulfonylurea
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Unknown mechanism results in decreased pioglitazone exposure
What To Tell Your Doctor or Pharmacist
If you are taking Topiramate and your doctor is considering prescribing Pioglitazone And Glimepiride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider