Does Tranylcypromine Interact with Metoclopramide?
CDI records a contraindicated classification for Tranylcypromine and Metoclopramide. The stored summary is: Product Clinical Comment on Concomitant Use [See Contraindications (4.1)] ; Predominant Effect/Risk [Hypertensive Reaction (HR) [See Warnings and Precautions (5.3)] ; or Serotonin Syndrome (SS) [See Warnings and Precautions (5.7)] ] Altretamine Use with caution If not otherwise specified in this table, consider avoiding concomitant use (see also information on medication-free intervals , use agent at the lowest appropriate dose, monitor for effects of the interaction, advise the patient to report potential effects, and be prepared to discontinue the agent and treat effects of the interaction Orthostatic hypotension [See Warnings and Precautions (5.5)] Buspirone Contraindicated HR Carbamazepine Contraindicated SS Chlorpromazine Use with caution Hypotensive effects Cyclobenzaprine Contraindicated SS Dextromethorphan Contraindicated SS; Psychosis, bizarre behavior Dopamine Contraindicated HR Droperidol Use with caution QT interval prolongation Entacapone Use with caution HR Fentanyl Use with caution SS Hydroxytryptophan Contraindicated SS Levodopa Contraindicated HR Lithium Use with caution SS Meperidine Contraindicated SS Methadone Use with caution SS Methyldopa Contraindicated HR Metoclopramide Use with caution HR/SS Mirtazapine Contraindicated SS Oxcarbazepine Use with caution because of close structural relationship with tricyclic antidepressants SS Rasagiline Contraindicated HR Reserpine Contraindicated HR S-adenosyl-L-methionine (SAM-e) Contraindicated SS Tapentadol Contraindicated HR/SS Tetrabenazine Contraindicated HR Tolcapone Use with caution HR Tramadol Use with caution SS; Increased seizure risk Tryptophan Contraindicated SS 7.2 Tyramine-Containing Foods and Beverages Tranylcypromine tablets inhibits intestinal MAO, which is responsible for the catabolism of tyramine in food and beverages. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
Evidence status
A current label comparison is not yet available for this record. The summary and severity are stored CDI information; they have not been independently validated on this page against the exact product label.
Confirm the medicine, formulation, route, and applicable warning with your pharmacist or prescriber. Independent clinical review has not been recorded.
- Stored CDI classification
- Contraindicated
- Management
- Confirm exact products with your pharmacist
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Tranylcypromine and your doctor is considering prescribing Metoclopramide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider