Tranylcypromine + Metoclopramide Interaction

Description

e [S ee Warnings and Precautions (5.5)]; f [S ee Warnings and Precautions (5.14)]; g [S ee Overdosage (10.1)] Table 4: Clinically Significant Drug Interactions with Individual Products* P r oduct C linical Comment on Concomitant Usea P r e dominant Effect/Risk [Hypertensive Reaction (HR)b or Serotonin Syndrome (SS)c] Altretamine Use with cautiond Orthostatic hypotensione Buspirone Contraindicateda HR Carbamazepine Contraindicateda SS Chlorpromazine Use with cautiond Hypotensive effectse Cyclobenzaprine Contraindicateda SS Dextromethorphan Contraindicateda SS; Psychosis, bizarre behavior Dopamine Contraindicateda HR Droperidol Use with cautiond QT interval prolongation Entacapone Use with cautiond HR Fentanyl Use with cautiond SS Hydroxytryptophan Contraindicateda SS Levodopa Contraindicateda HR Lithium Use with cautiond SS Meperidine Contraindicateda SS Methadone Use with cautiond SS Methyldopa Contraindicateda HR Metoclopramide Use with cautiond HR/SS Mirtazapine Contraindicateda SS Oxcarbazepine Use with cautiond because of close structural relationship with tricyclic antidepressants SS Rasagiline Contraindicateda HR Reserpine Contraindicateda HR S-adenosyl-L-methionine (SAM-e) Contraindicateda SS Tapentadol Contraindicateda HR/SS Tetrabenazine Contraindicateda HR Tolcapone Use with cautiond HR Tramadol Use with cautiond SS; Increased seizure risk Tryptophan Contraindicateda SS * Some drugs in this table may also belong to groups listed in Table 3 above, and may be associated with additional interactions.