Does Trimethoprim Interact with Lamivudine Oral?
CDI records a moderate classification for Trimethoprim and Lamivudine Oral. The stored summary is: Potential interaction possible due to similar renal elimination pathways via organic cationic transport system. Monitor for interactions. The mechanism involves both drugs eliminated via active organic cationic secretion in the kidney. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Trimethoprim Class
- Dihydrofolate Reductase Inhibitor Antibacterial
- Lamivudine Oral Class
- Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Both drugs eliminated via active organic cationic secretion in the kidney
What To Tell Your Doctor or Pharmacist
If you are taking Trimethoprim and your doctor is considering prescribing Lamivudine Oral (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider