Does Valproic Acid Interact with Lacosamide?
Valproic Acid and Lacosamide have a minor drug interaction according to U.S. FDA drug labeling data. Valproic acid 600 mg/day had no influence on lacosamide 400 mg/day pharmacokinetics, and lacosamide had no influence on valproic acid pharmacokinetics. The mechanism involves no clinically significant interaction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Valproic Acid Class
- Anti-epileptic Agent
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Valproic Acid and Lacosamide occurs because no clinically significant interaction. Clinically, this means valproic acid 600 mg/day had no influence on lacosamide 400 mg/day pharmacokinetics, and lacosamide had no influence on valproic acid pharmacokinetics. This is classified as a minor interaction with generally low clinical significance, though your healthcare provider should still be informed that you are taking both medications.
What To Tell Your Doctor or Pharmacist
If you are taking Valproic Acid and your doctor is considering prescribing Lacosamide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider