Does Valproic Acid Interact with Lacosamide?
CDI records a minor classification for Valproic Acid and Lacosamide. The stored summary is: Valproic acid 600 mg/day had no influence on lacosamide 400 mg/day pharmacokinetics, and lacosamide had no influence on valproic acid pharmacokinetics. The mechanism involves no clinically significant interaction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Minor
- Valproic Acid Class
- Anti-epileptic Agent
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
No clinically significant interaction
What To Tell Your Doctor or Pharmacist
If you are taking Valproic Acid and your doctor is considering prescribing Lacosamide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider