Does Venlafaxine Interact with Haloperidol?
CDI records a major classification for Venlafaxine and Haloperidol. The stored summary is: Venlafaxine decreases oral-dose clearance of haloperidol by 42%, resulting in 70% increase in haloperidol AUC and 88% increase in Cmax. The mechanism involves unknown. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Unknown
What To Tell Your Doctor or Pharmacist
If you are taking Venlafaxine and your doctor is considering prescribing Haloperidol (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider