Does Venlafaxine Hcl Er Interact with Ketoconazole?
Venlafaxine Hcl Er and Ketoconazole have a moderate drug interaction according to U.S. FDA drug labeling data. Increases venlafaxine and O-desmethylvenlafaxine AUC and Cmax. Caution when using venlafaxine with substances that inhibit both CYP2D6 and CYP3A4. The mechanism involves cyp2d6 and cyp3a4 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Ketoconazole Class
- Azole Antifungal
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Venlafaxine Hcl Er and Ketoconazole occurs because cyp2d6 and cyp3a4 inhibition. Clinically, this means increases venlafaxine and o-desmethylvenlafaxine auc and cmax. caution when using venlafaxine with substances that inhibit both cyp2d6 and cyp3a4. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Venlafaxine Hcl Er and your doctor is considering prescribing Ketoconazole (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider