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Does Venlafaxine Hydrochloride Interact with Cimetidine?

Venlafaxine Hydrochloride and Cimetidine have a moderate drug interaction according to U.S. FDA drug labeling data. Cimetidine reduces venlafaxine oral clearance by 43% and increases AUC and Cmax by 60%. Caution advised in patients with hypertension, elderly patients, or those with hepatic dysfunction. The mechanism involves inhibition of first-pass metabolism of venlafaxine. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Cimetidine Class
Histamine-2 Receptor Antagonist
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Venlafaxine Hydrochloride and Cimetidine occurs because inhibition of first-pass metabolism of venlafaxine. Clinically, this means cimetidine reduces venlafaxine oral clearance by 43% and increases auc and cmax by 60%. caution advised in patients with hypertension, elderly patients, or those with hepatic dysfunction. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.

What To Tell Your Doctor or Pharmacist

If you are taking Venlafaxine Hydrochloride and your doctor is considering prescribing Cimetidine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Venlafaxine Hydrochloride(Venlafaxine Hydrochloride)+💊 Cimetidine(Cimetidine)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Histamine-2 Receptor Antagonist
Source
NLP:venlafaxine hydrochloride

What this means in plain English

Cimetidine reduces venlafaxine oral clearance by 43% and increases AUC and Cmax by 60%. Caution advised in patients with hypertension, elderly patients, or those with hepatic dysfunction.

What the FDA label says

"Inhibition of first-pass metabolism of venlafaxine"

📖 Source: NLP:venlafaxine hydrochloride

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.